Deeper process knowledge is critical to facilitate efficient bioprocess development and manufacturing. Real-time monitoring of upstream process parameters by ProCellics™ Raman Analyzer with Bio4C™ PAT Raman Software speeds up process data acquisition and enables advanced control of quality attributes.
Mammalian cell cultures are widely used as the workhorse platform in the production of biological products such as antibodies or other therapeutic proteins. Deviations of critical process parameters (CPP) in upstream operations can directly lead to physicochemical and biological heterogeneities in the biological expression system and associated critical quality attributes (CQA) in therapeutic products. Hence, Process Analytical Technologies (PAT) represent an enabler to the Quality by Design (QbD) paradigm to generate adaptive processes that can maintain productivity and reduce product quality deviations through the implementation of process monitoring and control sensors.
Date: Thursday October 21, 2021
Time: 10am ET
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