Apply now! 2024 North America Advance Biotech Grant Program

Apply to our Advance Biotech Grant Program and get a chance to benefit from products, services, and consultations from experts. Applications are open until April 30th, 2024.

How Process Monitoring Tunnels Ensure Product Quality and Improve Process Performance

With a process monitoring tunnel you can monitor 100s of CPPs in a single graphical interface that captures the overall health – both past and present – of your bioprocess and reliably predicts its future health.

Biopharmaceutical Application Guide

Biopharmaceutical Application Guide helps overcome process challenges

Take a few minutes and navigate through our mAb, ADC, mRNA, Vaccine, and Cell and Gene Therapy process templates. Go ahead and dive into each unit operation to uncover the best option for your process.

Optimizing AAV Manufacturing: Process Intensification with High Salt Lysis and Salt Tolerant Endonuclease

The AAV vector manufacturing process involves cell lysis and nuclease treatment. Advanced techniques, such as using high salt concentration and a salt-tolerant endonuclease, can enhance vector titer and infectivity. Additionally, the development of a non-animal origin, salt-tolerant Benzonase® endonuclease has shown significant impact on AAV5 capsid titers and AAV2 vector infectivity.

Watch Now! Principles and Lessons Learned from the Benzonase® Success Story

In this webinar, you will learn:
• Key principles of Business Continuity Management
• Best practices for a robust supply chain
• How it translates into success stories, like with the Benzonase® family.

Turning potential into reality for gene therapy

• The gene therapy field is poised to deliver an increasingly broad and impactful set of treatments across many different diseases.
• A linchpin for success is a robust, cost-efficient, and scalable viral vector manufacturing workflow.
• Standardized production methods and fit-for-purpose workflow technologies are now available to address the unique development and manufacturing needs of viral vectors.
• Access to the necessary capacity and expertise along with strategies for a simplified pathway to GMP manufacturing, a shorter process development timeline, and a reduction in the exorbitant fixed costs associated with facility development are also available to help realize the true potential of gene therapy manufacturing space.

Two operators in a lab operating a Raman system and analyzing the data from their bioprocess activities.

Applications and Uses of Raman Spectroscopy in Bioprocessing

• Raman spectroscopy enables inline and real-time assessment of crucial process parameters and critical quality attributes during process development and manufacturing.
• It employs a chemometric approach to identify, quantify, and measure the concentration of key compounds in complex liquid media during upstream (USP) or downstream (DSP) processes.

Two operators in a lab operating a Raman system and analyzing the data from their bioprocess activities.

Unlocking Bioprocessing Insights: Exploring Chemometrics with Raman Spectroscopy

• Chemometrics is an interdisciplinary field that uses mathematical, statistical, and computer methods to extract valuable information from analytical data.
• When combined with Raman spectroscopy, chemometrics allows for the analysis of relevant data, enabling the generation of detailed insights on bioprocess activities and the development of more efficient models.

On Demand Webinar – Unleashing the Power of Perfusion: Cell Line Development for Intensified Processes

In this webinar, you will learn about:
• Optimizing the CLD process for stable, high-performing perfusion clones.
• Incorporating perfusion scale-down models into your CLD workflow.
• Using Mobius® Breez for final clone selection and cost-effective perfusion process development.
• Importance of using the right media for cell line expansion and production during CLD.

How Process Monitoring Tunnels Ensure Product Quality and Improve Process Performance

With a process monitoring tunnel you can monitor 100s of CPPs in a single graphical interface that captures the overall health – both past and present – of your bioprocess and reliably predicts its future health.

Biopharmaceutical Application Guide

Biopharmaceutical Application Guide helps overcome process challenges

Take a few minutes and navigate through our mAb, ADC, mRNA, Vaccine, and Cell and Gene Therapy process templates. Go ahead and dive into each unit operation to uncover the best option for your process.

Vaccines Technology Transfer: the foundation for a new era of vaccine production

This whitepaper provides an overview of the technology transfer process and describes the development and optimization of a platform to manufacture a vaccine for tropical diseases.

Supply Spotlight

Coming Full Circle with Biopharma Recycling

This post discusses the environmental challenges posed by the Biopharmaceutical industry’s heavy reliance on single-use systems and the resulting plastic waste. It highlights the industry’s quest for sustainable solutions through advanced recycling methods to achieve circularity.

Climate Neutrality in the Biopharma Industry, How Do We Get There?

To achieve climate target goals, Life Science companies need to put sustainability at the front of business decisions.

Can we change the Biopharma Supply Chain Game so that Everyone Gets a Trophy?

There is a popular board game based on a global disease outbreak that is generally rated 5 stars.  As for the real Covid-19 pandemic, it would be hard to find a single person in the Biopharma industry who would give the supply chain performance during the pandemic that kind of high review.

Vaccines

How Process Monitoring Tunnels Ensure Product Quality and Improve Process Performance

With a process monitoring tunnel you can monitor 100s of CPPs in a single graphical interface that captures the overall health – both past and present – of your bioprocess and reliably predicts its future health.

Biopharmaceutical Application Guide

Biopharmaceutical Application Guide helps overcome process challenges

Take a few minutes and navigate through our mAb, ADC, mRNA, Vaccine, and Cell and Gene Therapy process templates. Go ahead and dive into each unit operation to uncover the best option for your process.

Vaccines Technology Transfer: the foundation for a new era of vaccine production

This whitepaper provides an overview of the technology transfer process and describes the development and optimization of a platform to manufacture a vaccine for tropical diseases.

Two operators in a lab operating a Raman system and analyzing the data from their bioprocess activities.

Applications and Uses of Raman Spectroscopy in Bioprocessing

• Raman spectroscopy enables inline and real-time assessment of crucial process parameters and critical quality attributes during process development and manufacturing.
• It employs a chemometric approach to identify, quantify, and measure the concentration of key compounds in complex liquid media during upstream (USP) or downstream (DSP) processes.

Two operators in a lab operating a Raman system and analyzing the data from their bioprocess activities.

Unlocking Bioprocessing Insights: Exploring Chemometrics with Raman Spectroscopy

• Chemometrics is an interdisciplinary field that uses mathematical, statistical, and computer methods to extract valuable information from analytical data.
• When combined with Raman spectroscopy, chemometrics allows for the analysis of relevant data, enabling the generation of detailed insights on bioprocess activities and the development of more efficient models.

Optimizing AAV Manufacturing: Process Intensification with High Salt Lysis and Salt Tolerant Endonuclease

The AAV vector manufacturing process involves cell lysis and nuclease treatment. Advanced techniques, such as using high salt concentration and a salt-tolerant endonuclease, can enhance vector titer and infectivity. Additionally, the development of a non-animal origin, salt-tolerant Benzonase® endonuclease has shown significant impact on AAV5 capsid titers and AAV2 vector infectivity.

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