Breaking perceptions of TFF in gene therapy manufacturing

by Ratish Krishnan | June 27, 2023

The tangential flow filtration (TFF) unit operation in viral vector manufacturing is a critical step on the path to commercialization. In this episode, Ratish Krishnan and Akshat Gupta discuss best practices – and common misconceptions – when establishing process conditions and utilizing different TFF device formats.

Below are some of the questions discussed during the podcast:

How and why is tangential flow filtration (TFF) used in viral vector manufacturing?
What are the main types of TFF formats and membranes used in viral vector purification?
What are the key factors and best practices when it comes to designing a TFF step?

Learn how best practices can be applied on different TFF formats to overcome common concerns in viral vectors.

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Ratish Krishnan

Senior Strategy Consultant

Ratish Krishnan is a Senior Strategy Consultant in the Novel Modalities BioProcessing group for the Americas. He is passionate about providing solutions to bring treatments to market. A Process Development Scientist by background, he has over 13 years of experience in vaccine, monoclonal antibodies and viral vector modalities from pre-clinical to late stage process characterization, validation and commercialization activities such as BLA authoring.