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Two operators in a lab operating a Raman system and analyzing the data from their bioprocess activities.

Unlocking Bioprocessing Insights: Exploring Chemometrics with Raman Spectroscopy

• Chemometrics is an interdisciplinary field that uses mathematical, statistical, and computer methods to extract valuable information from analytical data.
• When combined with Raman spectroscopy, chemometrics allows for the analysis of relevant data, enabling the generation of detailed insights on bioprocess activities and the development of more efficient models.

Optimizing AAV Manufacturing: Process Intensification with High Salt Lysis and Salt Tolerant Endonuclease

The AAV vector manufacturing process involves cell lysis and nuclease treatment. Advanced techniques, such as using high salt concentration and a salt-tolerant endonuclease, can enhance vector titer and infectivity. Additionally, the development of a non-animal origin, salt-tolerant Benzonase® endonuclease has shown significant impact on AAV5 capsid titers and AAV2 vector infectivity.

On Demand Webinar – Unleashing the Power of Perfusion: Cell Line Development for Intensified Processes

In this webinar, you will learn about:
• Optimizing the CLD process for stable, high-performing perfusion clones.
• Incorporating perfusion scale-down models into your CLD workflow.
• Using Mobius® Breez for final clone selection and cost-effective perfusion process development.
• Importance of using the right media for cell line expansion and production during CLD.

Watch Now! Principles and Lessons Learned from the Benzonase® Success Story

In this webinar, you will learn:
• Key principles of Business Continuity Management
• Best practices for a robust supply chain
• How it translates into success stories, like with the Benzonase® family.

Two operators in a lab operating a Raman system to monitor upstream bioprocess CPPs and CQAs in-line and in real time.

Raman Spectroscopy as an advanced PAT Tool For In-Line and Real-Time Monitoring of Bioprocesses

• Raman spectroscopy enables non-destructive analysis of chemical composition and molecular structure.
• It provides real-time and in-situ measurements, allowing for sample preservation.
• Raman spectroscopy captures diverse biological and chemical information within a single spectrum and enables identification of specific molecules based on their distinct spectral signatures.

Apply now! 2024 North America Advance Biotech Grant Program

Apply to our Advance Biotech Grant Program and get a chance to benefit from products, services, and consultations from experts. Applications are open until April 30th, 2024.

Turning potential into reality for gene therapy

• The gene therapy field is poised to deliver an increasingly broad and impactful set of treatments across many different diseases.
• A linchpin for success is a robust, cost-efficient, and scalable viral vector manufacturing workflow.
• Standardized production methods and fit-for-purpose workflow technologies are now available to address the unique development and manufacturing needs of viral vectors.
• Access to the necessary capacity and expertise along with strategies for a simplified pathway to GMP manufacturing, a shorter process development timeline, and a reduction in the exorbitant fixed costs associated with facility development are also available to help realize the true potential of gene therapy manufacturing space.

PAT involves the use of different technologies such as chromatography, spectroscopy, or mass spectroscopy to enable real-time monitoring and control of the process.

How to Build Quality into Biopharmaceutical Processes with Real-Time Monitoring and Control

• Implementation of PAT into your bioprocesses ensures quality in biopharmaceutical manufacturing through real-time monitoring and control
• Analytical methods of monitoring and control of identified critical process parameters and critical quality attributes allows PAT to ensure quality of bioprocesses

How Process Monitoring Tunnels Ensure Product Quality and Improve Process Performance

With a process monitoring tunnel you can monitor 100s of CPPs in a single graphical interface that captures the overall health – both past and present – of your bioprocess and reliably predicts its future health.

Unlock the value of a complete solution for viral vector production

• While gene therapies can offer remarkable outcomes for patients, realizing their full potential requires an efficient workflow for viral vector production.
• Faced with limited process development and manufacturing expertise, gene therapy innovators can partner with integrated solution providers to fill these gaps and ensure a robust, optimized, and scalable viral vector production process.
• An integrated solution provider offers significant advantages in contrast to an assemblage of multiple suppliers focused on individual workflow steps which may lack a holistic view of operations.

Biopharmaceutical Application Guide

Biopharmaceutical Application Guide helps overcome process challenges

Take a few minutes and navigate through our mAb, ADC, mRNA, Vaccine, and Cell and Gene Therapy process templates. Go ahead and dive into each unit operation to uncover the best option for your process.

Maximize AAV Vector Production from Suspension HEK293 Cells

• Viral vectors are the most reliable and sought-after method for gene delivery.
• Use of adherent cell culture for manufacturing these vectors, however, can lead to limited cell growth, lower productivity, and necessitate use of animal-derived media supplements which increase the risk of introducing adventitious agents.
• The VirusExpress® 293 AAV production platform reduces risk and accelerates timelines with use of chemically defined animal component-free cell culture media that has been optimized for viral vector manufacturing.

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